The operate of SIK1 in tumorigenesis. SIK1 is actually a tumor suppressor gene, which performs a crucial regulatory function in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and impacts most cancers cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 could also endor

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